Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2008
[N-ras and fms gene mutation in idiopathic thrombocytopenic purpura and myelodysplasia].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Zhao Hong-Yu, Hou Ming, Li Xiao-Fang, Ma Dao-Xin, Liu Qi-Ji, Wang Pin
Аннотация
OBJECTIVE: To explore the pathogenesis of idiopathic thrombocytopenic purpura (ITP) and improve the differential diagnosis from myelodysplastic syndromes (MDS).
METHODS: Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) was performed to detect the point mutation of codon 12,13 in N-ras gene and codon 301, 969 in fms gene in adult and aged ITP and MDS patients.
RESULTS: In 25 ITP patients, N-ras mutation and fms mutation were detected in one each (4%). Mutations were found in 3 of 8 MDS patients: two (25%) with N-ras mutation and one (12.5%) with fms mutation.
CONCLUSIONS: Patients with N-ras or fms gene mutation diagnosed as MDS rather than ITP.
METHODS: Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) was performed to detect the point mutation of codon 12,13 in N-ras gene and codon 301, 969 in fms gene in adult and aged ITP and MDS patients.
RESULTS: In 25 ITP patients, N-ras mutation and fms mutation were detected in one each (4%). Mutations were found in 3 of 8 MDS patients: two (25%) with N-ras mutation and one (12.5%) with fms mutation.
CONCLUSIONS: Patients with N-ras or fms gene mutation diagnosed as MDS rather than ITP.