Journal of diabetes investigation · 2023
Imeglimin-mediated glycemic control in maternally inherited deafness and diabetes.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Ishibashi Ryoichi, Hirayama Kiichi, Watanabe Suzuka, Okano Kosuke, Kuroda Yuta, Baba Yusuke, Kanayama Takuma, Ito Chiho, Kasahara Keisuke, Aiba Saki, Iga Ryo, Ohtani Ryohei, Inaba Yosuke, Koshizaka Masaya, Maezawa Yoshiro, Yokote Koutaro
Аннотация
Mitochondrial dysfunction causes maternally inherited deafness and diabetes (MIDD). Herein, we report improved glycemic control in a 47-year-old Japanese woman with MIDD using imeglimin without major adverse effects. Biochemical tests and metabolome analysis were performed before and after imeglimin administration. Blood glucose level fluctuations were determined. Sulfonylureas, dipeptidyl peptidase-4 inhibitors (DPP4is), and sodium glucose transporter-2 inhibitors (SGLT2i) were administered to evaluate the efficacy of their combination with imeglimin. Imeglimin decreased the HbA1c and ammonia levels and increased the time-in-range, C-peptide reactivity, and glucagon level. Elevated citrulline and histamine levels were decreased by imeglimin. The hypoglycemic effect was not enhanced by imeglimin when combined with sulfonylurea or DPP4i, but the blood glucose level was improved when combined with SGLT2i. Imeglimin improved glucose concentration-dependent insulin secretion and maximized the insulin secretory capacity by improving mitochondrial function and glutamine metabolism and urea circuit abnormalities by promoting glucagon secretion. Imeglimin could improve glycemic control in MIDD.