[Leptin, adiponectin and sex hormone in benign acanthosis nigricans of males].

OBJECTIVE

To explore the serum levels of leptin, adiponectin and sex hormone and their relationship in benign acanthosis nigricans of males.

METHODS

A total of 15 males patients with benign acanthosis nigricans were recruited from January 2010 to December 2013. The serum concentrations of leptin, adiponectin and sex hormone were measured with radioimmunoassay and enzyme-linked immunoabsorbant assay (ELISA) respectively.

RESULTS

As compared with normal control, the values of body mass, body mass index and %Fat were much higher in benign acanthosis nigricans of males ((88 ± 6) vs (62 ± 5) kg, (31.7 ± 2.1) vs (22.2 ± 2.7) kg/m(2), 33.3% ± 2.6% vs 29.0% ± 5.8%, all P < 0.05) , leptin was much higher ((8.0 ± 1.1) vs (4.5 ± 1.5) µg/L, P < 0.01) , adiponectin was much lower ((27.7 ± 4.8) vs (38.6 ± 5.8) µg/L, P < 0.01) , estradiol and testosterone were much higher ((112 ± 28) vs (38 ± 7) pmol/L, (7.3 ± 1.9) vs (3.9 ± 2.0) nmol/L, both P < 0.01), luteinizing hormone was much lower ((128 ± 11) vs (155 ± 24) U/L, P < 0.01) . And prolactin and follicle stimulating hormone were not significantly different between two groups (both P > 0.05).

CONCLUSIONS

Benign acanthosis nigricans is associated with abnormal levels of lepin, adiponectin and sex hormone. And there may be some relationship between the abnormal levels of lepin and sex hormone in benign acanthosis nigricans.