Gram-Negative Uropathogens in Diabetic Patients: A Study of Ampicillinase Cephalosporinase, Extended-Spectrum Beta-Lactamases, and Metallo Beta-Lactamases Producing Phenotypes.

AIM: This study aimed to identify Gram-negative uropathogens (GN-UP)-producing extended-spectrum beta-lactamases (ESBL), metallo-beta-lactamases (MBL), and AmpC enzymes in diabetic patients and to analyze their antibiotic resistance profiles.

MATERIALS AND

METHODS

Urine samples were cultured, and isolates were tested using the Kirby-Bauer disc diffusion method.

RESULTS

E. coli (43%) was the most common isolate, followed by Klebsiella spp. (25%). Among GN-UP, 13.26% were ESBL producers, 63.26% MBL producers, and 17.34% AmpC producers. MBL-producing isolates showed lower resistance to fosfomycin (22.58%), tigecycline (32.25%), and nitrofurantoin (33.87%). The high prevalence of MBL, ESBL, and AmpC producers in diabetic urinary tract infection (UTI) patients complicates effective antibiotic therapy.

CONCLUSION

These findings underscore the need for regular antimicrobial surveillance and tailored treatment strategies in this vulnerable group.