Cureus · 2024
Antimicrobial Resistance Patterns of Clinically Isolated Strains of Acinetobacter baumannii in a Tertiary Care Hospital in Libya.
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Thwood Dalal, Alghadem Zynab, Elgriw Nada, Hnaya Maren, Zaghdani Ahmed, El Meshri Salah Edin, Elzagheid Adem
Аннотация
OBJECTIVE: Acinetobacter baumannii accounts for a notable percentage of hospital-acquired infections. The widespread resistance to multiple antibiotic classes complicates treatment efforts. This study aims to find out the pattern of susceptibility of multidrug-resistant A. baumannii (MDRAB) isolated from clinical specimens to antibiotics recommended for testing and use for A. baumannii and to determine a local guide at Tripoli University Hospital (TUH), Tripoli, Libya for the empirical antibiotic treatment of MDRAB based on the susceptibility pattern identified.
MATERIALS AND METHODS: This retrospective cross-sectional study was carried out in the Department of Microbiology at TUH in Libya from January 2021 to June 2021. Identification of isolates was performed using the VITEK® 2 automated system (bioMérieux, France), and the isolates were categorized as susceptible, intermediate susceptible, or resistant according to the minimum inhibitory concentration (MIC).
RESULTS: A total of 86 A. baumannii isolates were obtained from various clinical specimens from different departments. Isolates show high resistance to most of the tested antibiotics. Beta-lactams and ciprofloxacin were found to be the most resistant, while the highest susceptibility was detected to minocycline and amikacin.
CONCLUSION: These findings prompt clinicians to consider taking minocycline and amikacin into account when starting empirical therapy for severe infections caused by A. baumannii.
MATERIALS AND METHODS: This retrospective cross-sectional study was carried out in the Department of Microbiology at TUH in Libya from January 2021 to June 2021. Identification of isolates was performed using the VITEK® 2 automated system (bioMérieux, France), and the isolates were categorized as susceptible, intermediate susceptible, or resistant according to the minimum inhibitory concentration (MIC).
RESULTS: A total of 86 A. baumannii isolates were obtained from various clinical specimens from different departments. Isolates show high resistance to most of the tested antibiotics. Beta-lactams and ciprofloxacin were found to be the most resistant, while the highest susceptibility was detected to minocycline and amikacin.
CONCLUSION: These findings prompt clinicians to consider taking minocycline and amikacin into account when starting empirical therapy for severe infections caused by A. baumannii.