A Randomized, Double-blind, Split-face Trial Evaluating the Safety and Efficacy of a Serum Containing Plant Adaptogens Versus Moisturizing Lotion Pre- and Post-fractional Laser in Patients with Mild-to-moderate Photodamage.

OBJECTIVE

We aimed to evaluate the safety and efficacy of a serum containing plant adaptogens (MYS) compared to a moisturizing lotion (ML) pre- and post-laser treatment.

METHODS

A double-blind, split-face controlled study enrolled women with mild-to-moderate photodamaged skin. Participants were randomized to twice-daily application of MYS and ML to one side of their face and ML only to the opposite side two weeks prior to and 10 days following a single, non-ablative fractional laser treatment. Tolerability and global skin healing were assessed immediately post-procedure and on Days 1, 2, 4, 7, and 10. Global skin quality (the total sum of scores for erythema, dullness, rough skin texture, pores, and uneven pigmentation) was calculated at baseline, Week 2 (pre-procedure/skincare only), and Day 10 (post-procedure).

RESULTS

Fifteen participants completed the study (mean age: 52 years). Significantly less dryness occurred on the MYS vs. the ML side of the face on Days 1 and 2 (p=0.05 and p=0.001, respectively), with less erythema on the MYS vs. the ML side (29% vs. 17%) on Day 2. Significant improvements occurred in global skin healing on the MYS vs. the ML side of the face on Days 1, 2, and 4 (p=0.04, p=0.003, and p=0.003, respectively) and in global skin quality at Week 2 and Day 10 (p=0.03 and p=0.001, respectively). All adverse events were temporary and related to the procedure.

CONCLUSION

Twice-daily application of a serum containing plant adaptogens before and after non-ablative fractional laser treatment demonstrated significant reductions in dryness and erythema, and improvements in global skin healing and skin quality compared to ML.