Медицинская библиотека · Antiviral therapy · 2006

Pegylated interferon-alpha for the treatment of sexually transmitted acute hepatitis C in HIV-infected individuals.

Vogel Martin, Nattermann Jacob, Baumgarten Axel, Klausen Gerd, Bieniek Bernhard, Schewe Knud, Jessen Heiko, Boesecke Christoph, Rausch Michael, Lutz Thomas, Fenske Stefan, Schranzo Dietmar, Kümmerle Tim, Schuler Christoph, Theisen Albert, Mayr Christoph, Seidel Thomas, Rockstroh Jürgen K

Клиническое исследованиеСтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

BACKGROUND

Sexually transmitted acute hepatitis C among HIV-positive homosexual men has been noted as an emerging epidemic.

METHODS

Forty-seven patients with mainly sexually acquired, acute hepatitis C were enrolled in this prospective, multicentre trial, and 36 of these patients were treated within the acute phase of hepatitis C infection with pegylated interferon (peg-IFN) therapy.

RESULTS

Early treatment resulted in sustained virological response in 61% of patients. Peg-IFN alone showed similar treatment response rates and lower incidence of anaemia compared with peg-IFN+ribavirin combination therapy. Higher treatment response rates were observed in patients treated over 48 weeks compared with 24 weeks.

CONCLUSIONS

Treatment of hepatitis C in HIV-positive individuals in the acute phase of infection leads to high rates of sustained virological response. Optimal time and mode of therapy have yet to be defined.

Для цитирования: Vogel Martin, Nattermann Jacob, Baumgarten Axel, Klausen Gerd, Bieniek Bernhard, Schewe Knud, Jessen Heiko, Boesecke Christoph, Rausch Michael, Lutz Thomas, Fenske Stefan, Schranzo Dietmar, Kümmerle Tim, Schuler Christoph, Theisen Albert, Mayr Christoph, Seidel Thomas, Rockstroh Jürgen K. Pegylated interferon-alpha for the treatment of sexually transmitted acute hepatitis C in HIV-infected individuals.. Antiviral therapy. 2006.

Предметные рубрики MeSH

Adult Antiviral Agents HIV Infections Hepatitis C Humans Interferon alpha-2 Interferon-alpha Male Polyethylene Glycols Recombinant Proteins Sexually Transmitted Diseases, Viral

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