Revista clinica espanola · 2009
[Agranulocytosis from metamizole: a potential problem for the British population].
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Mérida Rodrigo L, Faus Felipe V, Poveda Gómez F, García Alegría J
Аннотация
OBJECTIVE: Analyze the clinical and epidemiological features of this adverse effect and assess its incidence in the general population, especially in the British one.
METHODS: A descriptive, retrospective analysis of all the patients discharged at Hospital Costa del Sol (Marbella) with a main diagnosis of dipyrone-related agranulocytosis in the Minimum Basic Data Set (MBDS) from January 1998 to December 2003. Neutropenia was defined as severe (neutrophils lower than 500/ml), moderate (500-1000/ml) and mild (1000-1500/ml).
RESULTS: 13 patients developed dipyrone-related agranulocytosis, 8 of them foreign (61.5%) and 5 from United Kingdom. The rate of events was 8.33/106 inhabitants/year. With regard to British population registered in the area, the estimated rate of events was 20.4 cases/106 inhabitants/year.
CONCLUSION: Dipyrone-related agranulocytosis is an adverse effect more frequent in British population, and its use must be avoided.
METHODS: A descriptive, retrospective analysis of all the patients discharged at Hospital Costa del Sol (Marbella) with a main diagnosis of dipyrone-related agranulocytosis in the Minimum Basic Data Set (MBDS) from January 1998 to December 2003. Neutropenia was defined as severe (neutrophils lower than 500/ml), moderate (500-1000/ml) and mild (1000-1500/ml).
RESULTS: 13 patients developed dipyrone-related agranulocytosis, 8 of them foreign (61.5%) and 5 from United Kingdom. The rate of events was 8.33/106 inhabitants/year. With regard to British population registered in the area, the estimated rate of events was 20.4 cases/106 inhabitants/year.
CONCLUSION: Dipyrone-related agranulocytosis is an adverse effect more frequent in British population, and its use must be avoided.