F1000Research · 2025
The potential effects of cranberry extract on indomethacin-induced gastric ulcer in rats.
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Abdul-Majeed Zaid, Al-Atrakji Mohammed Qasim Yahya Malallah A
Аннотация
BACKGROUND: Indomethacin belongs to nonsteroidal anti-inflammatory drugs (NSAIDs) prescribed for treatment of rheumatoid diseases and linked to the development of gastric ulcers in many people. Cranberry is a rich source of polyphenols and flavonoids, which have powerful antioxidant and anti-inflammatory properties.
METHODS: This study aimed to evaluate the activity of cranberry aqueous extract on indomethacin-induced gastric ulcers in albino rats. 20 adult male rats were sequentially assigned to four groups of 5 each. The control group consumes distilled water (DW) orally for 15 days. The induction group received a single oral dosage (60 mg/kg) of IND. The omeprazole group got 60 mg/kg of indomethacin as a single oral dose and then 20 mg/kg/day of omeprazole for 15 days. The cranberry group was given a single dose of indomethacin 60 mg/kg orally and subsequently 200 mg/kg/day of cranberry aqueous extract for 15 days. Rats were euthanized on day 15, and gastric tissues were removed for biochemical and histopathological evaluations.
RESULTS: Cranberry extract considerably ameliorated the severity of indomethacin-induced gastric ulcerations and fixed histological deteriorations. Furthermore, indomethacin-exposed rats treated with cranberry extract exhibited dramatically lower serum levels of inflammatory biomarkers like TNF-α and IL-6, but higher levels of anti-oxidative biomarkers like SOD and GPx. The bioactive flavonoids and polyphenols content of cranberry extract could possibly account for its profound gastroprotective effects. The anti-oxidative and anti-inflammatory properties of cranberry extract could be a promising strategy for ameliorating the indomethacin-aggravated gastrotoxicity.
METHODS: This study aimed to evaluate the activity of cranberry aqueous extract on indomethacin-induced gastric ulcers in albino rats. 20 adult male rats were sequentially assigned to four groups of 5 each. The control group consumes distilled water (DW) orally for 15 days. The induction group received a single oral dosage (60 mg/kg) of IND. The omeprazole group got 60 mg/kg of indomethacin as a single oral dose and then 20 mg/kg/day of omeprazole for 15 days. The cranberry group was given a single dose of indomethacin 60 mg/kg orally and subsequently 200 mg/kg/day of cranberry aqueous extract for 15 days. Rats were euthanized on day 15, and gastric tissues were removed for biochemical and histopathological evaluations.
RESULTS: Cranberry extract considerably ameliorated the severity of indomethacin-induced gastric ulcerations and fixed histological deteriorations. Furthermore, indomethacin-exposed rats treated with cranberry extract exhibited dramatically lower serum levels of inflammatory biomarkers like TNF-α and IL-6, but higher levels of anti-oxidative biomarkers like SOD and GPx. The bioactive flavonoids and polyphenols content of cranberry extract could possibly account for its profound gastroprotective effects. The anti-oxidative and anti-inflammatory properties of cranberry extract could be a promising strategy for ameliorating the indomethacin-aggravated gastrotoxicity.