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Войти в исследования Behçet's disease as a causative factor of cerebral venous sinus thrombosis: subgroup analysis of data from the VENOST study.
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Uluduz Derya, Midi Ipek, Duman Taskin, Colakoglu Sena, Tüfekci Ahmet, Bakar Mustafa, Nazliel Bijen, Tascilar Nida, Goksan Baki, Sungur Mehmet Ali, Kozak Hasan Huseyin, Demir Serkan, Misirli Cemile Handan, Kucukoglu Hayriye, Cinar Nilgun, Domac Fusun Mayda, Ozturk Serefnur, Yayla Vildan, Karahan Ali Yavuz, Afsar Nazire, Goksu Eylem Ozaydin, Mengulluoglu Necdet, Aytac Emrah, Yesilot Nilufer, Ince Birsen, Yalin Ozgur Osman, Oruc Serdar, Demirci Seden, Senol Mehmet Guney, Yilmaz Arda, Gokce Mustafa, Yilmaz Kusbeci Özge, Uzuner Gulnur, Batur Caglayan Hale Zeynep, Acikgoz Mustafa, Zeydan Burcu, Ozdag Fatih, Baybas Sevim, Ekmekci Hakan, Cabalar Murat, Yaman Mehmet, Yurekli Vedat Ali, Tekeli Hakan, Genc Hamit, Utku Uygar, Ucan Tokuc Firdevs Ezgi, Uzuner Nevzat, Bektas Hesna, Kablan Yuksel, Goksel Basak K, Milanlioglu Aysel, Necioglu Orken Dilek, Aluclu Ufuk
Аннотация
METHODS: VENOST was a retrospective and prospective national multicentre observational study that included 1144 patients with CVST. The patients were classified according to aetiologic factors, time of CVST symptom onset, sinus involvement, treatment approach and prognosis.
RESULTS: BD was shown to be a causative factor of CVST in 108 (9.4%) of 1144 patients. The mean age of patients in the BD group was 35.27 years and 68.5% were men, whereas in the non-BD CVST group, the mean age was 40.57 years and 28.3% were men (P < 0.001). Among the aetiologic factors for patients aged 18-36 years, BD was predominant for men, and puerperium was predominant for women. The onset of symptoms in the BD group was consistent with the subacute form. The transverse sinuses were the most common sites of thrombosis, followed by the superior sagittal sinuses. The most common symptom was headache (96.2%), followed by visual field defects (38%).
CONCLUSIONS: BD was found in 9.4% of patients in our VENOST series. Patients with BD were younger and showed a male predominance. The functional outcome of CVST in patients with BD was good; only 12% of patients presenting with cranial nerve involvement and altered consciousness at the beginning had a poor outcome (modified Rankin Score ⩾2).