Changes in sodium and potassium excretion and urinary volume in rats submitted to hypervitaminosis A.

Hypervitaminosis A induces the following changes in rat kidney: decrease in sodium and potassium excretion and an increase of urinary volume. In order to determine the possible reversibility of these alterations, the authors allowed the hypervitaminotic animal to recover for 30 and 60 days. After a 30-day recovery period for urinary volume, a 20-day recovery period for sodium excretion, and a 10-day recovery period for potassium excretion, the alterations were reverted to normal.