Journal of pharmacy & bioallied sciences · 2025
Synthesis, Structural Analysis, and Antifungal Potential of Copper Oxide Nanoparticles against Candida Species.
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Zende Arti, Pawar Jayant, Khanwelkar Chitra, Phatak Rohan S
Аннотация
INTRODUCTION: Recurrent vaginal infections caused by Candida species, particularly drug-resistant strains, remain a major concern in women's reproductive health.
AIM: This study evaluates the antifungal potential of copper oxide nanoparticles (CuO NPs), synthesized via a semi-solvothermal method, against clinically relevant vaginal Candida species-Candida albicans, C. glabrata, C. tropicalis, and C. krusei.
MATERIALS AND METHODS: Structural and optical characterization confirmed a crystalline cubic phase (XRD), a strong UV-Vi's absorption at 340 nm with a 3.4 eV band gap, and spherical nanoparticles (10-25 nm) seen via FESEM. Antifungal activity was tested using agar well diffusion and CFU assays across 15-1000 μg/mL concentrations.
RESULT: A concentration-dependent colony forming unit (CFU) reduction was observed, with C. krusei showing the highest sensitivity (MIC: 60 μg/mL; complete inhibition at 1000 μg/mL), followed by C. glabrata. C. albicans and C. tropicalis exhibited moderate to high resistance.
CONCLUSION: These findings highlight the potential of CuO NPs as a promising antifungal agent, particularly effective against resistant or non-albicans Candida species, offering an alternative strategy for treating vaginal candidiasis.
AIM: This study evaluates the antifungal potential of copper oxide nanoparticles (CuO NPs), synthesized via a semi-solvothermal method, against clinically relevant vaginal Candida species-Candida albicans, C. glabrata, C. tropicalis, and C. krusei.
MATERIALS AND METHODS: Structural and optical characterization confirmed a crystalline cubic phase (XRD), a strong UV-Vi's absorption at 340 nm with a 3.4 eV band gap, and spherical nanoparticles (10-25 nm) seen via FESEM. Antifungal activity was tested using agar well diffusion and CFU assays across 15-1000 μg/mL concentrations.
RESULT: A concentration-dependent colony forming unit (CFU) reduction was observed, with C. krusei showing the highest sensitivity (MIC: 60 μg/mL; complete inhibition at 1000 μg/mL), followed by C. glabrata. C. albicans and C. tropicalis exhibited moderate to high resistance.
CONCLUSION: These findings highlight the potential of CuO NPs as a promising antifungal agent, particularly effective against resistant or non-albicans Candida species, offering an alternative strategy for treating vaginal candidiasis.