Audiology & neuro-otology · 2015
Effect of corticosteroids on facial function after cerebellopontine angle tumor removal: a double-blind study versus placebo.
СтатьяМногоцентровое исследованиеРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Bozorg Grayeli Alexis, Ferrary Evelyne, Tubach Florence, Bernat Isabelle, Deguine Olivier, Darrouzet Vincent, Robier Alain, Zaouche Sandra, Dubreuil Christian, Marx Mathieu, Kalamarides Michel, Fraysse Bernard, Sterkers Olivier
Аннотация
The aim of this study was to assess the effect of corticosteroids administered intra- and postoperatively on the occurrence of facial palsy after a cerebellopontine angle (CPA) tumor resection, and to investigate pre- and intraoperative prognostic factors. A multicenter, prospective, randomized, double-blind and versus-placebo study was conducted between 2006 and 2010. Three hundred and ten patients operated on for a CPA tumor (96% vestibular schwannomas, 4% miscellaneous) were included by five participating centers. The population was stratified into patients with small (≤15 mm CPA on axial MRI views) and large tumors. In each group, patients were randomized to receive corticosteroid (1 mg/kg/day i.v. methylprednisolone intraoperatively and at postoperative days 1-5) or placebo. Steroids did not affect the facial function at postoperative days 1, 8 and 30 in patients with small or large tumors as evaluated by House and Brackmann grading.