Clinical neurology and neurosurgery · 2012
Modification of altered ankle motor control after stroke using focal application of botulinum toxin type A.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Tang Simon F, Hong Jia-Pei, McKay William Barry, Tang Chu-Wen, Wu Pei-Hsuan, Chu Ngok-Kiu
Аннотация
STUDY DESIGN: Blinded, placebo-controlled, prospective clinical trial.
PURPOSE: To examine the effects of botulinum toxin type A (BTX-A) injections into plantar flexor muscles in stroke patients with equinovarus gait.
SUBJECTS: 15 post-stroke and 10 matched neurologically intact subjects.
METHODS: Modified Ashworth Scale (MAS) and Fugl-Meyer assessment of physical function scale scores along with surface EMG collected before and up to 12 weeks after BTX-A injections to plantar flexor muscle motor points in stroke subjects. Saline placebo injections were performed in a subset of stroke subject group.
RESULTS: MAS scores were decreased at 4, 8 and 12 weeks but F-M scores did not improve until 12 weeks post injection. Multi-muscle EMG patterns showed the return of volitional dorsiflexor activity in 11 and a decrease of antagonistic and distant coactivation in all but one of the 15.
CONCLUSIONS: BTX-A is effective in reducing antagonistic and distant muscle activation that impedes volitional dorsiflexion.
PURPOSE: To examine the effects of botulinum toxin type A (BTX-A) injections into plantar flexor muscles in stroke patients with equinovarus gait.
SUBJECTS: 15 post-stroke and 10 matched neurologically intact subjects.
METHODS: Modified Ashworth Scale (MAS) and Fugl-Meyer assessment of physical function scale scores along with surface EMG collected before and up to 12 weeks after BTX-A injections to plantar flexor muscle motor points in stroke subjects. Saline placebo injections were performed in a subset of stroke subject group.
RESULTS: MAS scores were decreased at 4, 8 and 12 weeks but F-M scores did not improve until 12 weeks post injection. Multi-muscle EMG patterns showed the return of volitional dorsiflexor activity in 11 and a decrease of antagonistic and distant coactivation in all but one of the 15.
CONCLUSIONS: BTX-A is effective in reducing antagonistic and distant muscle activation that impedes volitional dorsiflexion.