[Advances in antimicrobial peptides combination therapy strategies against drug-resistant bacterial infections].

The persistent spread of multidrug-resistant bacteria (MDR) infections has become a major challenge in global public health, severely limiting treatment options with traditional antimicrobial drugs and leading to a significant increase in patient mortality. Antimicrobial peptides, as small-molecule effectors within the innate immune system, demonstrate significant potential in combating MDR infections due to their unique membrane-disrupting mechanisms, broad-spectrum antimicrobial activity, and low propensity to induce resistance. However, the monotherapy of antimicrobial peptides still faces challenges such as poor stability, rapid degradation in vivo, and potential resistance risks. To overcome these limitations, recent research has increasingly focused on combination strategies for antimicrobial peptides. By synergistically combining antimicrobial peptides with traditional antibiotics, other antimicrobial peptides, nanomaterials, or phage lysins, these approaches aim to enhance bactericidal effects and delay the development of resistance. This systematic review summarizes the latest research advances in antimicrobial peptides combination therapy for infection control, emphasizing synergistic mechanisms. Current challenges and future directions are discussed to provide a theoretical foundation and practical insights for developing novel anti-infective treatment regimens.