Therapeutic value of Gramurin (oxolinic acid) in Shigella infections and Shigella-negative dysentery syndrome.

A total of 10 Shigella-positive and 10 Shigella-negative dysentery syndrome patients were treated with daily 2-g Gramurin doses for 3 days. Favourable clinical results could be obtained in response to the therapy. The complaints of the patients ceased within 48 hours. Bacterial negativity was recorded on days 3, 4, and 5 after cessation of therapy in Shigella flexneri-positive cases (5 cases), while in case of Shigella sonnei positivity bacterium negativity could be obtained within the abovementioned period in only 3 out of the 5 cases. The presented results of Gramurin therapy in Shigella infections and Shigella-negative dysentery syndrome are virtually congruent with the earlier reported favourable observations of the authors with the drug in these conditions.