Treating Fungal Keratitis with Oral Voriconazole Only: A Case Series.

BACKGROUND

To report the clinical effect of oral voriconazole only as a treatment for fungal keratitis.

HISTORY AND SIGNS: Three patients (1 female and 2 males) with culture-proven fungal keratitis (1 Mucoraceae, 1 Aspergillus, 1 Fusarium) were included in this study. The patients were treated with oral voriconazole 200 mg twice daily to observe the clinical response in the treatment of fungal keratitis.

THERAPY AND OUTCOME: The mean age of the patients was 51 years and the average treatment duration was 6 weeks. The corneal inflammation in these three patients was eliminated by oral voriconazole only.

CONCLUSIONS

This is the first reported case of oral voriconazole only as a treatment for fungal keratitis. We found that oral voriconazole has a significant clinical effect on the treatment of fungal keratitis.