Experimental infection with Ancylostoma caninum larvae in mice. VII. Role of promethazine hydrochloride in the rejection of worm burden from the intestine.

Acquired resistance of female swiss albino mice (6 to 8 weeks old) to Ancylostoma caninum infection was demonstrated by the transfer of mesenteric lymph node cells (MLNC) from resistant (sensitised and promethazine treated), sensitised and untreated and non-sensitised and untreated donors to normal recipients of the same isogeneic strain. MLNC from sensitised and promethazine treated donors were more effective in suppressing the rejection mechanism of worm burden in recipients in comparison to the cells obtained from other donor groups; the drug may be exerting an inhibitory action at either the specific lymphoid level (reducing antibodies effect) and at the non-specific amine level.