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Войти в исследования The American journal of gastroenterology · 2021
Risk Factors for Delta Hepatitis in a North American Cohort: Who Should Be Screened?
СтатьяResearch Support, N.I.H., IntramuralНазвание и аннотация: Перевод в очереди
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Da Ben L, Rahman Farial, Lai Walter C, Kleiner David E, Heller Theo, Koh Christopher
Аннотация
INTRODUCTION: The American Association for the Study of Liver Diseases recommends hepatitis D virus (HDV) screening in certain high-risk groups; however, the effectiveness is unknown.
METHODS: A study of North American patients with hepatitis B (HBV) referred to the NIH was performed to identify risk factors associated with HDV infection. Active HDV was "confirmed" by serum HDV RNA or histologic HDV antigen staining.
RESULTS: Six hundred fifty-two were studied, of which 91 were HDV "confirmed." Independent risk factors for HDV included: intravenous drug users, HBV-DNA <2,000 IU/mL, alanine aminotransferase >40 U/L, and HDV endemic country of origin.
DISUSSION: North American patients with HBV and significant risk factors should be screened for HDV.
METHODS: A study of North American patients with hepatitis B (HBV) referred to the NIH was performed to identify risk factors associated with HDV infection. Active HDV was "confirmed" by serum HDV RNA or histologic HDV antigen staining.
RESULTS: Six hundred fifty-two were studied, of which 91 were HDV "confirmed." Independent risk factors for HDV included: intravenous drug users, HBV-DNA <2,000 IU/mL, alanine aminotransferase >40 U/L, and HDV endemic country of origin.
DISUSSION: North American patients with HBV and significant risk factors should be screened for HDV.
Предметные рубрики MeSH
AdultAlanine TransaminaseAlkaline PhosphataseAspartate AminotransferasesCohort StudiesCoinfectionDNA, ViralEmigrants and ImmigrantsEndemic DiseasesFemaleHepatitis AntibodiesHepatitis B, ChronicHepatitis DHepatitis delta AntigensHumansMaleMass ScreeningMiddle AgedPlatelet CountProthrombin TimeRNA, ViralRetrospective StudiesRisk AssessmentRisk FactorsSerum AlbuminSubstance Abuse, IntravenousUnited StatesViral Loadgamma-Glutamyltransferase