The Anthelmintic Activity of 0,0-dimethyl-0-1,2-dibromo-2,2-dichloroethyl phosphate for Canine Hookworms.

In a statistical study involving 18 adult dogs an enterically coated, tableted formulation of 0,0-dimethyl-0-1,2-dibromo-2,2-dichloroethyl phosphate was found to clear 86.5 per cent of the dogs of hookworm infections when given orally at a level of 15 mg./kg. for 2 consecutive days and 50 per cent when it was given at the same level once. The per-cent efficacy for hookworm removal was 70 and 78 per cent respectively. The dogs were infected with both A. caninum and U. stenocephala. Other concurrent helminth infections were also present.No vomitions, symptoms, or lesions of drug toxicity were observed in the medicated dogs.