Lung cancer (Amsterdam, Netherlands) · 2007
Syndrome of inappropriate antidiuretic hormone secretion and ectopic ACTH production in small cell lung carcinoma.
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Müssig Karsten, Horger Marius, Häring Hans-Ulrich, Wehrmann Manfred
Аннотация
BACKGROUND: Small cell lung carcinoma (SCLC) is frequently associated with a paraneoplastic syndrome.
CASE REPORT: We report on a rare case of SCLC presenting with syndrome of inappropriate antidiuretic hormone (SIADH) secretion and ectopic ACTH production. In accordance with the endocrine evaluation, immunohistochemical staining of the tumour was positive for ADH and ACTH. Chemotherapy with etoposide and carboplatin induced a nearly complete remission.
CONCLUSION: Simultaneous secretion of ADH and ACTH is infrequently reported with only five cases described in the literature. SIADH in patients with ectopic ACTH syndrome may be underdiagnosed due to the antagonistic hormone actions of cortisol and ADH on renal sodium excretion.
CASE REPORT: We report on a rare case of SCLC presenting with syndrome of inappropriate antidiuretic hormone (SIADH) secretion and ectopic ACTH production. In accordance with the endocrine evaluation, immunohistochemical staining of the tumour was positive for ADH and ACTH. Chemotherapy with etoposide and carboplatin induced a nearly complete remission.
CONCLUSION: Simultaneous secretion of ADH and ACTH is infrequently reported with only five cases described in the literature. SIADH in patients with ectopic ACTH syndrome may be underdiagnosed due to the antagonistic hormone actions of cortisol and ADH on renal sodium excretion.
Предметные рубрики MeSH
ACTH Syndrome, EctopicAdrenocorticotropic HormoneAntineoplastic AgentsAntineoplastic Agents, PhytogenicAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCarcinoma, Small CellEtoposideFemaleHumansImmunohistochemistryInappropriate ADH SyndromeLung NeoplasmsMiddle AgedRadiographyRemission Induction