Hepatology (Baltimore, Md.) · 2015
A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Verrier Eloi R, Colpitts Che C, Bach Charlotte, Heydmann Laura, Weiss Amélie, Renaud Mickaël, Durand Sarah C, Habersetzer François, Durantel David, Abou-Jaoudé Georges, López Ledesma Maria M, Felmlee Daniel J, Soumillon Magali, Croonenborghs Tom, Pochet Nathalie, Nassal Michael, Schuster Catherine, Brino Laurent, Sureau Camille, Zeisel Mirjam B, Baumert Thomas F
Аннотация
UNLABELLED: Chronic hepatitis B and D infections are major causes of liver disease and hepatocellular carcinoma worldwide. Efficient therapeutic approaches for cure are absent. Sharing the same envelope proteins, hepatitis B virus and hepatitis delta virus use the sodium/taurocholate cotransporting polypeptide (a bile acid transporter) as a receptor to enter hepatocytes. However, the detailed mechanisms of the viral entry process are still poorly understood. Here, we established a high-throughput infectious cell culture model enabling functional genomics of hepatitis delta virus entry and infection. Using a targeted RNA interference entry screen, we identified glypican 5 as a common host cell entry factor for hepatitis B and delta viruses.
CONCLUSION: These findings advance our understanding of virus cell entry and open new avenues for curative therapies. As glypicans have been shown to play a role in the control of cell division and growth regulation, virus-glypican 5 interactions may also play a role in the pathogenesis of virus-induced liver disease and cancer.
CONCLUSION: These findings advance our understanding of virus cell entry and open new avenues for curative therapies. As glypicans have been shown to play a role in the control of cell division and growth regulation, virus-glypican 5 interactions may also play a role in the pathogenesis of virus-induced liver disease and cancer.