PLoS pathogens · 2026
Experimental hepatitis E virus genotype 1 infection in three types of wild rodents.
СтатьяНазвание и аннотация: Перевод в очереди
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Zhang He, Wu Yang, Wang Haojie, Liu Tianxu, Liu Xing, Chen Jianxing, Sun Yue, Xue Lihong, Li Changwen, Liu Huairan, Chen Hongyan, Qi Yinglin, An Tongqing, Wang Liang, Jin Zhimin, Yu Changqing, Yang Xinyue, Li Yuebao, Li Hui, Xia Changyou, Yin Xin, Wang Lin
Аннотация
Hepatitis E virus genotype 1 (HEV-1) has long been considered human-specific, with no known natural animal hosts. Here, we demonstrate that three wild rodent species-Apodemus peninsulae, Clethrionomys rufocanus, and Lasiopodomys brandtii-are susceptible to HEV-1 infection. Among them, A. peninsulae infected with HEV-1 exhibited the highest susceptibility, characterized by robust fecal viral shedding, systemic viral replication, seroconversion, and mild liver pathology mimicking human acute HEV-1 infection. Intrahepatic transcriptomic analysis of infected animals revealed activation of inflammatory pathways, including upregulation of IL-1β and IL-18. Re-inoculation experiments confirmed infection-induced protective immunity, and ribavirin treatment effectively suppressed viral replication. HEV-1 infection can be established by oral gavage inoculation, close contact and vertical transmission. These results provide solid evidence that wild rodents can serve as potential hosts for HEV-1, highlighting the potential role of wild rodents in HEV-1 ecology and cross-species transmission.