Le infezioni in medicina · 2010
Fatal reactivation of HBV and HDV during a long-lasting interruption of HAART in a patient co-infected with HIV, HCV, HBV and HDV.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Polilli Ennio, Sozio Federica, Mazzotta Elena, Pieri Alessandro, Alterio Luciana, Placido Elena, Agostinone Adriana, Di Masi Francesco, Tontodonati Monica, Consorte Augusta, Cosentino Luana, Parruti Giustino
Аннотация
Coinfection by the Human Immunodeficiency Virus (HIV) and hepatitis viruses is a frequent condition in drug addicts. In the present study we report on the case of a patient with a history of drug and alcohol abuse who was sequentially infected with HIV, HCV, HBV and HDV. He died of an overwhelming reactivation of HBV and HDV in spite of a recent interferon treatment. HBV and HDV resumed their active replication after over 20 years of complete latency, that is after long-lasting viral undetectability, when the patient deliberately discontinued his last HAART regimen. HBV and HDV reactivated in spite of a relatively preserved immune system and a recent immune stimulatory treatment with pegylated interferon.
Предметные рубрики MeSH
AlcoholismAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveDrug Administration ScheduleFatal OutcomeHIV InfectionsHIV Protease InhibitorsHepatitis B virusHepatitis B, ChronicHepatitis C, ChronicHepatitis DHepatitis Delta VirusHumansImmunocompromised HostKidney DiseasesLiver FailureMaleMiddle AgedMyocardial InfarctionReverse Transcriptase InhibitorsSubstance Abuse, IntravenousVirus Activation