Presse medicale (Paris, France : 1983) · 1998
[Enterobacter aerogenes pneumopathy treated by a cefepime-sulbactam-gentamicin combination].
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Mardrus P, Le Grand J L, Chardon H, Garrigues B
Аннотация
BACKGROUND: Enterobacter aerogenes is the fifth most frequent pathogen causing nosocomial infections. Several strains have developed multiple resistance by over-production of a natural cephalosporinase and by the presence of wide-spectrum betalactamases.
CASE REPORT: A patient with chronic respiratory failure developed Enterobacter aerogenes pneumonia while under mechanical ventilation. The infection was successfully treated with a cefepime, sulbactam, gentamycin combination.
DISCUSSION: Choosing the optimum antibiotic therapy is a difficult task in many nosocomial infections. In certain cases, combining a betalactamase inhibitor with the appropriate antibiotic can improve bactericidal activity and provide successful cure.
CASE REPORT: A patient with chronic respiratory failure developed Enterobacter aerogenes pneumonia while under mechanical ventilation. The infection was successfully treated with a cefepime, sulbactam, gentamycin combination.
DISCUSSION: Choosing the optimum antibiotic therapy is a difficult task in many nosocomial infections. In certain cases, combining a betalactamase inhibitor with the appropriate antibiotic can improve bactericidal activity and provide successful cure.
Предметные рубрики MeSH
Anti-Bacterial AgentsCefepimeCephalosporinsChronic DiseaseCross InfectionDrug Resistance, MicrobialDrug Resistance, MultipleDrug Therapy, CombinationEnterobacterEnterobacteriaceae InfectionsGentamicinsHumansMaleMiddle AgedPneumonia, BacterialRespiration, ArtificialRespiratory InsufficiencySulbactamTreatment Outcome