Nickel-Catalyzed Regio- and Diastereoselective Ring-Opening Reductive Coupling of Methylenecyclopropanes with Aldehydes.

Transition-metal-catalyzed selective transformations of strained small ring systems are of great significance yet challenging. Herein, we disclose a nickel-catalyzed regio- and diastereoselective ring-opening reductive coupling of methylenecyclopropanes with aldehydes. The method offers an efficient route to bishomoallylic alcohols under mild conditions with a broad substrate scope (37 examples), good functional group tolerance, and generally high diastereoselectivity.