Polyneuropathy due to cyclosporine A in patients with renal transplantation: a case report.

BACKGROUND

Calcineurin inhibitor cyclosporine A (CsA) is a potent immunosuppressive agent. The side effects of CsA include nephrotoxicity, hypertension, hypertrichosis, infection, hyperpotassemia, and, to a lower extent, neuropathy.

OBJECTIVES

In this case report, we aimed to present a renal transplant patient with polyneuropathy (PNP) due to the use of CsA and with improvement when switched to rapamycin.

METHODS

In electromyography, axonal sensory PNP was detected. CsA was stopped and rapamycin was begun.

RESULTS

His complaints rapidly improved after using rapamycin.

CONCLUSIONS

Patients using CsA should be closely monitored for peripheral neuropathy and in case of toxicity, alternative immunosuppressive agents should be considered.