The effect of topical doxycycline on corneal neovascularization.

PURPOSE: To examine the effect of topical doxycycline on human corneal neovascularization (CONV).

MATERIALS AND

METHODS

Six eyes of six patients with CONV received topical 1% doxycycline four times per day for three weeks and monitored for a total of one year. Ophthalmic evaluations included visual acuity, tonometry, slit-lamp examination, conjunctival swabs, quantification of CONV and photography.

RESULTS

CONV either disappeared or was attenuated, shortened and less dense in five of six patients. There were no adverse effects.

CONCLUSION

Topical doxycycline was effective in reducing CONV and healing of the ocular surface.