Proteomics dataset of lysolecithin-induced demyelinated lesions in corpus callosum of Lewis rats, treated with Vagus nerve stimulation or sham treatment.

This article presents a comprehensive proteomics dataset from a lysolecithin (LPC)-induced demyelination model in the corpus callosum of female Lewis rats. The LPC model, widely used in preclinical studies of toxic demyelination, serves as a valuable tool for investigating processes of demyelination and remyelination, as well as for testing potential remyelination therapies for diseases like Multiple Sclerosis. In this study, rats received either Vagus Nerve Stimulation (VNS) or a sham treatment. Proteomic analysis via LC-MS/MS was performed to assess the impact of these treatments on inflammation and remyelination and to further explore the mechanism of VNS action. This dataset complements the findings reported in the article "Vagus Nerve Stimulation enhances remyelination and decreases innate neuroinflammation in lysolecithin-induced demyelination" [1], providing a detailed account of the proteomics methods and results, including the quantification of 8172 proteins. This dataset allows for further exploration of key mechanisms in the LPC model by comparing different time points within the sham group. Additionally, comparisons between the sham and VNS groups can be extended or combined with other published datasets to gain deeper insights into the effects of VNS. Raw data are available via ProteomeXchange with identifier PXD050858.