Definition of delayed-onset neurologic sequelae: A review article.

BACKGROUND

Delayed-onset neurologic sequelae (DNS) is a devastating complication of carbon monoxide poisoning. Despite abundant research studies on DNS, the definition remains unclear, with a wide range of symptoms. This review aims to identify the different symptoms and definitions that have been associated with DNS in available research.

METHODS

For this review, searches were conducted in PubMed and Scopus. Two authors screened research studies by abstract and title, and a third resolved conflicts. After the full-text review, one author extracted the data. Only original full-text research studies in English with a clear definition of DNS were included.

RESULTS

This review included 127 studies. Signs and symptoms associated with DNS were categorized into twelve groups. The most used symptom categories to define DNS were general neurological and cognitive/learning dysfunctions. Imaging studies, clinical testing, and neuropsychiatric testing used to define DNS were also documented.

CONCLUSIONS

The literature did not consistently define DNS attributed to CO toxicity. Standardizing the definition and diagnostic criteria would benefit clinical research.