Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology · 2015
[IMMUNOGENETICS AND PROGRESSION OF CHRONIC VIRAL HEPATITES].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Beloborodova E V, Goncharova I A, Beloborodova E I, Purlik I L, Kalacheva T P, Akbasheva O E, Rachkovskiy M I, Burkovskaya V A
Аннотация
AIM OF INVESTIGATION: To estimate the role of polymorphic variants of genes IL4 (C-590T), IL4RA (I50V), TNF (G-308A) and SLC1IAI (D543N) in chronic viral hepatitis progression.
MATERIAL AND METHODS: Overall 121 patients with chronic viral hepatitis C and B.
RESULTS: Study results have demonstrated, that of all investigated polymorphic variants of genes IL4 (C-590T), IL4RA (150V), TNF (G-308A) and SLC11A1 (D543N) in patients with chronic liver diseases of various etiology the <<Val/Val>> IL4RA gene variant (II50Val) is associated with HBV-infection chronization. The allele <<A>> gene TNF-α (G-308A) is protective for chronic viral hepatitis and is associated with a low level of production by mononuclear cells of TNF-α and IL-12, high secretion of IL-4 and low degree of collagenopathy in the liver. Genotype <<CT>> of IL4 (C-590T) gene is an adverse marker for progression of chronic viral hepatitis B. There was significant correlation of polymorphic variants TNF (G-308A) and IL4 (C-590T) genes with production of the key interleukins, that determine type of immune response (Th-1, Th-2) and products of collagen metabolism that testifies genetic determination of system immune response and collagen formation processes in the liver at chronic viral hepatitis.
MATERIAL AND METHODS: Overall 121 patients with chronic viral hepatitis C and B.
RESULTS: Study results have demonstrated, that of all investigated polymorphic variants of genes IL4 (C-590T), IL4RA (150V), TNF (G-308A) and SLC11A1 (D543N) in patients with chronic liver diseases of various etiology the <<Val/Val>> IL4RA gene variant (II50Val) is associated with HBV-infection chronization. The allele <<A>> gene TNF-α (G-308A) is protective for chronic viral hepatitis and is associated with a low level of production by mononuclear cells of TNF-α and IL-12, high secretion of IL-4 and low degree of collagenopathy in the liver. Genotype <<CT>> of IL4 (C-590T) gene is an adverse marker for progression of chronic viral hepatitis B. There was significant correlation of polymorphic variants TNF (G-308A) and IL4 (C-590T) genes with production of the key interleukins, that determine type of immune response (Th-1, Th-2) and products of collagen metabolism that testifies genetic determination of system immune response and collagen formation processes in the liver at chronic viral hepatitis.