Internal medicine (Tokyo, Japan) · 2016
Recurrence of Psoriasis Vulgaris Accompanied by Treatment with C-C Chemokine Receptor Type 4 (CCR4) Antibody (Mogamulizumab) Therapies in a Patient with Adult T cell Leukemia/ Lymphoma: Insight into Autoinflammatory Diseases.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Morichika Kazuho, Tomoyose Takeaki, Hanashiro Taeko, Shimabukuro Natsuki, Tamaki Keita, Tedokon Iori, Nishi Yukiko, Nakachi Sawako, Karube Ken-Nosuke, Fukushima Takuya, Katoh Takeharu, Ohshima Koichi, Masuzaki Hiroaki
Аннотация
Adult T cell leukemia / lymphoma (ATL) is one of the most aggressive hematological malignancies caused by human T-lymphotropic virus type-I (HTLV-1). Mogamulizumab is a new defucosylated humanized monoclonal antibody agent which targets C-C chemokine receptor type 4 (CCR4) expressed occasionally on the surface of ATL cells. However, adverse events such as drug eruptions have also been highlighted, at least in part, via the dysfunction of regulatory T cells (Tregs). We herein report a pronounced recurrence of systemic psoriasis vulgaris accompanied by the treatment of mogamulizumab in a patient with ATL. Pathological examinations may suggest a mechanistic link between the recurrence of autoinflammatory diseases and anti-CCR4 antibody therapies.