Distribution of HCV genotypes in Poland.
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Panasiuk Anatol, Flisiak Robert, Mozer-Lisewska Iwona, Adamek Agnieszka, Tyczyno Małgorzata, Halota Waldemar, Pawłowska Małgorzata, Stańczak Janusz, Berak Hanna, Wawrzynowicz-Syczewska Marta, Boroń-Kaczmarska Anna, Łapiński Tadeusz Wojciech, Grzeszczuk Anna, Piekarska Anna, Tomasiewicz Krzysztof, Jabłkowski Maciej, Kryczka Wiesław, Zarebska-Michaluk Dorota, Stepień Piotr, Garlicki Aleksander Michał, Kozłowska Joanna, Wiercińska-Drapało Alicja, Zasik Ewelina, Mazur Waldemar, Dobracka Bozena, Dobracki Witold, Simon Krzysztof, Ryzko Józef, Pawłowska Joanna, Dzierzanowska-Fangrat Katarzyna, Januszkiewicz-Lewandowska Danuta, Szenborn Leszek, Zaleska Izabela, Rokitka Maria, Strawińska Elzbieta, Balinowska Katarzyna, Smiatacz Tomasz, Stalke Piotr, Sikorska Katarzyna, Lakomy Anna, Zdrojewski Maciej, Lachowicz Anna
Аннотация
MATERIAL AND METHODS: Analysis of HCV genotypes in Poland was carried out between 2003 and 2012, and included 14 651 patients from 22 centers where patients with chronic viral hepatitis C are diagnosed and treated. Genotypes were analyzed in age groups (< 20 years of age, 20-40 years of age, > 40 years of age) as well as in populations of HBV and HIV co-infections.
RESULTS: Genotype (G) 1 infection was demonstrated in 79.4%, G2 -0.1%, G3- 13.8%, G4- 4.9%, G6-0.09% and mixed infections in 1.6%. There was no infection with genotype 5. The highest prevalence of G1 was observed in the Łódzkie voivodship (89.2%) and the Slaskie voivodship (86.7%) while the lowest one in the Warmińsko-mazurskie (62.0%) and the Podlaskie voivodships (68.2%). Genotype 3 most commonly occurs in the Warmińsko-mazurskie (28.1%), and the Podlaskie voivodships (23.0%) and is least common in the Małopolskie (7.9%) and the Łódzkie voivodships (9.0%). Genotype 4 is more common in the Kujawsko-pomorskie (11.7%) and the Podlaskie voivodships (8.6%) and relatively less common in the Lubelskie (1.1%) and the Łódzkie voivodships (1.8%). Prevalence of G1 infection in 2003-2004 was 72% and increased up to 85.6% in 2011-2012, that was accompanied by decrease of G3 prevalence from 17% to 8% in this period. In HBV co-infected (n = 83), G1 infection was demonstrated in 85.5%, G3 - in 7.2%, G4 -4.8%, and mixed genotypes in 6%. Among HIV co-infected (n = 391), a much lower prevalence of G1 (33.0%) and a high of G3 (40.4%) as well as G4 (24.0%) were observed.
CONCLUSIONS: There is a geographic variability of HCV genotypes prevalence in Poland. Increase of HCV G1 infections and decrease of G3 and G4 were observed in the last 10 years. Genotypes G3 and G4 occur more often in HCV/HIV co-infected than in HCV mono-infected patients.