Engineered probiotic for hepatic encephalopathy.

Hepatic encephalopathy is a devastating neuroinflammatory complication of cirrhosis driven by systemic metabolic dysregulation across the gut-liver-brain axis. In a recent article in Cell, Aggarwal et al. engineered a multi-strain bacterial cocktail to simultaneously neutralize toxic ammonia and L-glutamine while replenishing essential amino acids, offering a promising, targeted therapeutic strategy.