Indomethacin blocks acute audiologic effects of furosemide in Meniere's disease.

The acute audiologic effects of glycerin and furosemide were measured with and without indomethacin pretreatment in two patients. The positive effects of glycerin were not blocked by indomethacin. The positive effect of furosemide on discrimination score was blocked by indomethacin. The concomitant rise in plasma renin level after furosemide was also blocked by indomethacin. A role for prostaglandins in inner ear fluid dynamics is suggested by this study. It appears that glycerin and furosemide affect inner ear fluid dynamics by different mechanisms.