[Problems occurred after Helicobacter pylori eradication and their countermeasures].

Acute esophagogastroduodenal mucosal lesions are the demonstrable adverse events occurred after H. pylori eradication. In our study, acute duodenal erosions were observed in 13.5% of the eradicated patients. Duodenal erosions which occurred mainly at the early phase after eradication were temporal and asymptomatic. Acute gastric erosion showed the same clinical manner. However, it needs to pay attention for rare occurrence of acute ulcers with severe symptoms. On the other hand, mild but persistent reflux esophagitis occurred at relatively late phase after eradication. Their occurrence rates were 9.8% after 1 year and 11.4% after 3 years. Acute mucosal lesions occurred probably due to the increase of acid output accompanied with the recovery of gastritis. Symptomatic treatment with antacids were need occasionally for acute ulcer and reflux esophagitis.