Nerve-racking worms.

The enteric nervous system is a key regulator of inflammation, crosstalking directly with the immune system at the mucosal surfaces of the gastrointestinal tract. In this issue of Immunity, Wang and colleagues demonstrate that intrinsic enteric neurons (iENs) sense interleukin (IL)-13 to restrain group 2 innate lymphoid cell (ILC2) activity during helminth infection, uncovering a novel neuro-immune-regulatory circuit.