Neuroendocrine tumor of the uterine cervix: a clinicopathologic study of 14 cases.

PURPOSE: The study explored the clinicopathologic characteristics of the neuroendocrine tumor of uterine cervix (NTUC).

METHODS

The general information and the clinical-pathological characteristics of 14 NTUC cases were reviewed.

RESULTS

The median age of the cases was 41 years. Six cases (42.9 %) were FIGO stage Ib1, four cases (28.6 %) were Ib2, one case was IIa2 (7.1 %), one case (7.1 %) was IIb, one case (7.1 %) was IIIb and one case (7.1 %) was IVb. Radical hysterectomy and bilateral salpingo-oophorotomy plus pelvic lymphadenectomy were performed on seven cases: three cases had radical hysterectomy plus pelvic lymphadenectomy; one case had transabdominal hysterectomy; and one case had a residual cervical resection. Four cases had positive pelvic lymph nodes. Two cases (14.3 %) had the tumor infiltrated to the parametrium and five cases (35.7 %) to lymphovascular space. One case had positive margin of vagina. Nine cases (64.3 %) were administered post-surgery radiotherapy and all cases were given adjuvant chemotherapy. The median follow-up time was 10 months. The median disease-free survival was 6 months, and the median total survival time was 18 months. The median estimated survival time was 32.0 months (95 % CI 16.9-47.1 months).

CONCLUSIONS

NTUC is a very rare malignant tumor of female genital tract. Multi-center cooperation to gather more cases is the best method to explore the biological behavior and for the proper treatment of NTUC.