Clinical study of corneal response to the wear of low water content soft lenses.

The changes in central and peripheral corneal thickness and topography during initial (1st-day) wear, adaptation to, and long-term wear of the DuraSoft lens were monitored in a group of 10 patients. Monitoring was by means of the electronic digital pachometer and the photoelectronic keratoscope (PEK). A variety of physiological responses to lens wear was noted in individual patients, but generally the changes occurring were comparable to those reported for other soft lenses. These changes consisted of an average increase of 5-6% in central and peripheral corneal thickness during the initial phase of wear and 4-5% during adaptation; this was followed by a reduction with long-term wear to 2-3%. Corneal topography was relatively stable throughout the period of the study.