Neuropsychobiology · 2004
Psychobiological aspects of somatoform disorders: contributions of monoaminergic transmitter systems.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Rief Winfried, Pilger Florian, Ihle Daniel, Verkerk Robert, Scharpe Simon, Maes Michael
Аннотация
OBJECTIVE: To evaluate the possible biological aspects of 'unexplained physical symptoms', this study examined serotonergic and noradrenergic monoamino acids in somatoform disorders and/or depression.
METHODS: Blood samples of 150 subjects from 4 groups (somatization syndrome; depression; depression and somatization; controls) were analyzed for amino acids contributing to the serotonergic and noradrenergic system and peripheral muscle energy balance (tryptophan, valine, leucine, isoleucine, phenylalanine and tyrosine).
RESULTS: Tryptophan, branched chain amino acids and other serotonergic amino acids were decreased in patients with somatoform symptoms, even when no depression was present.
CONCLUSIONS: We conclude that serotonergic amino acids are biological correlates of multiple unexplained symptoms. Ways of action do not only involve brain mechanisms, but also energy metabolism in peripheral muscles.
METHODS: Blood samples of 150 subjects from 4 groups (somatization syndrome; depression; depression and somatization; controls) were analyzed for amino acids contributing to the serotonergic and noradrenergic system and peripheral muscle energy balance (tryptophan, valine, leucine, isoleucine, phenylalanine and tyrosine).
RESULTS: Tryptophan, branched chain amino acids and other serotonergic amino acids were decreased in patients with somatoform symptoms, even when no depression was present.
CONCLUSIONS: We conclude that serotonergic amino acids are biological correlates of multiple unexplained symptoms. Ways of action do not only involve brain mechanisms, but also energy metabolism in peripheral muscles.