Stress-induced rupioid psoriasis managed with ustekinumab.

We report the first case of stress-induced rupioid psoriasis, a rare and severe hyperkeratotic variant of psoriasis, arising after the sudden loss of a close relative. The patient achieved remarkable clearance with ustekinumab, highlighting the potential of interleukin (IL)-12/IL-23 blockade in this under-recognized phenotype. This case underscores the role of acute stress as a trigger, and the urgent need to better define the pathophysiology and tailored treatment of hyperkeratotic psoriasis variants.