Plant Extracts Downregulating the JAK/STAT Signaling Pathway as a Potential Tool for Psoriasis Management: A Review.

Background/Objectives: Among the Inflammatory Skin Diseases (ISDs), psoriasis represents a recalcitrant and disabling dermatological disorder associated with perpetuated inflammatory conditions. Recent findings showed that psoriasis pathogenesis is sustained by the interplay of different inflammatory Signaling Pathways, among which the JAK/STAT stands out. Methods: This review aims to investigate the state of the art and the most recent insights concerning the efficacy of plant extracts in psoriasis management via modulation of the JAK/STAT Signaling Pathway. Results: In vitro and in vivo studies revealed that several different plant species showed promising results in modulating the dysregulation of the JAK/STAT Signaling Pathway associated with psoriasis. Raw and enriched extracts and herbal remedy formulations were discussed. Then, present insights, future directions, and gaps of literature were addressed. Conclusions: Promising studies suggested that plant-based products, able to downregulate the JAK/STAT Signaling Pathway, could represent an effective tool for psoriasis management.