American journal of translational research · 2024
Sulfur cream blowing and parching combined with compound ketoconazole cream versus compound ketoconazole cream alone in patients with palmoplantar keratotic eczema: a pilot study.
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Qin Xiaomin, Chen Qi, Zhu Zibo, Li Jinjin, Kang Xu
Аннотация
BACKGROUND: Sulfur cream is reported to relieve itching and treat skin diseases caused by bacterial, fungal, and scabies infections. However, there is limited data on the efficacy of sulfur cream blowing and parching combined with compound ketoconazole ointment (ketoconazole, clobetasol propionate, and neomycin sulfate) in curing palmoplantar keratotic eczema. This prospective study proposed to investigate the clinical efficacy of sulfur cream on people who suffer with palmoplantar keratotic eczema.
METHODS: In total, 116 patients with palmoplantar keratotic eczema (those who met the diagnostic criteria of Expert Consensus on Standardized Diagnostic Terminology of Dermatitis and Eczematous Diseases) were chosen and divided into a control group (C, n = 58) and a study group (S, n = 58) depending on the treatment method. Patients in group C were cured with compound ketoconazole cream, while those in group S were given sulfur cream blowing and parching (10-15 min, once in the morning and once in the evening, with 4 weeks as a course of treatment) combined with compound ketoconazole cream treatment. Scores of erythema, keratinization, scales, chapping, pruritus, quality of life, and psychological status of patients were evaluated before and 4 weeks treatment.
RESULTS: The overall response rate (93% vs. 79%) and scores of quality of life, physiological burden, and social interaction of patients of group S were higher than those of group C (P < 0.05), and the incidence of adverse reactions and scores of self-rating anxiety scale, self-rating depressive scale, erythema, keratinization, scales, and skin lesions were lower in group S than those in the group C (P < 0.05) 4 weeks after treatment. In addition, pruritus scores at 1, 2, and 4 weeks after treatments were fewer in patients of group S than those in group C (P < 0.05).
CONCLUSIONS: Sulfur cream blowing and parching for 4 weeks of treatment combined with compound ketoconazole cream is more effective than compound ketoconazole cream alone for 4 weeks in treating palmoplantar keratotic eczema.
METHODS: In total, 116 patients with palmoplantar keratotic eczema (those who met the diagnostic criteria of Expert Consensus on Standardized Diagnostic Terminology of Dermatitis and Eczematous Diseases) were chosen and divided into a control group (C, n = 58) and a study group (S, n = 58) depending on the treatment method. Patients in group C were cured with compound ketoconazole cream, while those in group S were given sulfur cream blowing and parching (10-15 min, once in the morning and once in the evening, with 4 weeks as a course of treatment) combined with compound ketoconazole cream treatment. Scores of erythema, keratinization, scales, chapping, pruritus, quality of life, and psychological status of patients were evaluated before and 4 weeks treatment.
RESULTS: The overall response rate (93% vs. 79%) and scores of quality of life, physiological burden, and social interaction of patients of group S were higher than those of group C (P < 0.05), and the incidence of adverse reactions and scores of self-rating anxiety scale, self-rating depressive scale, erythema, keratinization, scales, and skin lesions were lower in group S than those in the group C (P < 0.05) 4 weeks after treatment. In addition, pruritus scores at 1, 2, and 4 weeks after treatments were fewer in patients of group S than those in group C (P < 0.05).
CONCLUSIONS: Sulfur cream blowing and parching for 4 weeks of treatment combined with compound ketoconazole cream is more effective than compound ketoconazole cream alone for 4 weeks in treating palmoplantar keratotic eczema.