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DOI 10.1101/2025.03.18.25324188

Медицинская библиотека · medRxiv : the preprint server for health sciences · 2025

Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup.

Harnett Nathaniel G, Joshi Soumyaa, Kumar Poornima, Russell Courtney, Dillon Daniel G, Baker Justin T, Pizzagalli Diego A, Kaufman Milissa L, Nickerson Lisa N, Jahanshad Neda, Salminen Lauren E, Thomopoulos Sophia I, Frijling Jessie L, Veltman Dick J, Koch Saskia B J, Nawijn Laura, van Zuiden Mirjam, Zhu Ye, Li Gen, Ipser Jonathan, Zhu Xi, Ravid Orren, Zilcha-Mano Sigal, Lazarov Amit, Suarez-Jimenez Benjamin, Sun Delin, Hussain Ahmed, Huggins Ashley A, Jovanovic Tanja, van Rooij Sanne J H, Fani Negar, Hudson Anna R, Sierk Anika, Manthey Antje, Walter Henrik, van der Wee Nic J A, van der Werff Steven J A, Vermeiren Robert R J M, Říha Pavel, Lebois Lauren A M, Rosso Isabelle M, Olson Elizabeth A, Liberzon Israel, Angstadt Mike, Disner Seth G, Sponheim Scott R, Koopowitz Sheri-Michelle, Hofmann David, Qi Rongfeng, Maron-Katz Adi, Kunch Austin, Xie Hong, El-Hage Wissam, Berg Hannah, Bruce Steven E, McLaughlin Katie A, Peverill Matthew, Sambrook Kelly, Ross Marisa, Herringa Ryan J, Nitschke Jack B, Davidson Richard J, deRoon-Cassini Terri A, Tomas Carissa W, Fitzgerald Jacklynn M, Blackford Jennifer Urbano, Olatunji Bunmi O, Nelson Steven M, Gordon Evan M, Densmore Maria, Théberge Jean, Neufeld Richard W J, Olff Miranda, Wang Li, Stein Dan J, Neria Yuval, Stevens Jennifer S, Mueller Sven C, Daniels Judith K, Rektor Ivan, King Anthony, Davenport Nicholas D, Straube Thomas, Lu Guangming, Etkin Amit, Wang Xin, Quidé Yann, Lissek Shmuel, Cisler Josh, Grupe Daniel W, Larson Christine, Feola Brandee, May Geoffrey, Abdallah Chadi G, Lanius Ruth, Thompson Paul M, Morey Rajendra A, Ressler Kerry

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Аннотация

BACKGROUND

Identifying robust neural signatures of posttraumatic stress disorder (PTSD) symptoms is important to facilitate precision psychiatry and help in understanding and treatment of the disorder. Emergent research suggests structural covariance of early visual regions is associated with later PTSD development. However, large-scale analyses are needed - in heterogeneous samples of trauma-exposed and trauma naive individuals - to determine if such a neural signature is a robust - and potentially a pretrauma - marker of vulnerability.

METHODS

We analyzed data from the ENIGMA-PTSD dataset (n = 2,814) and the Human Connectome Project - Young Adult (HCP-YA) dataset (n = 890) to investigate whether structural covariance of early visual cortex is associated with either PTSD symptoms or perceived stress. Structural covariance was derived from a multimodal pattern previously identified in recent trauma survivors, and participant loadings on the profile were included in linear mixed effects models to evaluate associations with stress.

RESULTS

Early visual cortex covariance loadings were negatively associated with PTSD symptoms in the ENIGMA-PTSD dataset. The relationship persisted when accounting for prior childhood maltreatment; supporting PTSD symptom specificity, no relationship was observed with depressive symptoms and no association was observed between loadings and perceived stress measures in the HCP-YA dataset.

CONCLUSION

Structural covariance of early visual cortex was robustly associated with PTSD symptoms across an international, heterogeneous sample of trauma survivors. Future studies should aim to identify specific mechanisms that underlie structural alterations in the visual cortex to better understand posttrauma psychopathology.

Для цитирования: Harnett Nathaniel G, Joshi Soumyaa, Kumar Poornima, Russell Courtney, Dillon Daniel G, Baker Justin T, Pizzagalli Diego A, Kaufman Milissa L, Nickerson Lisa N, Jahanshad Neda, Salminen Lauren E, Thomopoulos Sophia I, Frijling Jessie L, Veltman Dick J, Koch Saskia B J, Nawijn Laura, van Zuiden Mirjam, Zhu Ye, Li Gen, Ipser Jonathan, Zhu Xi, Ravid Orren, Zilcha-Mano Sigal, Lazarov Amit, Suarez-Jimenez Benjamin, Sun Delin, Hussain Ahmed, Huggins Ashley A, Jovanovic Tanja, van Rooij Sanne J H, Fani Negar, Hudson Anna R, Sierk Anika, Manthey Antje, Walter Henrik, van der Wee Nic J A, van der Werff Steven J A, Vermeiren Robert R J M, Říha Pavel, Lebois Lauren A M, Rosso Isabelle M, Olson Elizabeth A, Liberzon Israel, Angstadt Mike, Disner Seth G, Sponheim Scott R, Koopowitz Sheri-Michelle, Hofmann David, Qi Rongfeng, Maron-Katz Adi, Kunch Austin, Xie Hong, El-Hage Wissam, Berg Hannah, Bruce Steven E, McLaughlin Katie A, Peverill Matthew, Sambrook Kelly, Ross Marisa, Herringa Ryan J, Nitschke Jack B, Davidson Richard J, deRoon-Cassini Terri A, Tomas Carissa W, Fitzgerald Jacklynn M, Blackford Jennifer Urbano, Olatunji Bunmi O, Nelson Steven M, Gordon Evan M, Densmore Maria, Théberge Jean, Neufeld Richard W J, Olff Miranda, Wang Li, Stein Dan J, Neria Yuval, Stevens Jennifer S, Mueller Sven C, Daniels Judith K, Rektor Ivan, King Anthony, Davenport Nicholas D, Straube Thomas, Lu Guangming, Etkin Amit, Wang Xin, Quidé Yann, Lissek Shmuel, Cisler Josh, Grupe Daniel W, Larson Christine, Feola Brandee, May Geoffrey, Abdallah Chadi G, Lanius Ruth, Thompson Paul M, Morey Rajendra A, Ressler Kerry. Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup.. medRxiv : the preprint server for health sciences. 2025. DOI: 10.1101/2025.03.18.25324188.
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