Polymorphisms of the SCN10A Gene in Patients With Sick Sinus Syndrome.

PURPOSE: To study association of rs6795970 polymorphism of SCN10A gene with development of idiopathic sick sinus syndrome (ISSS).

MATERIALS AND

METHODS

We examined 109 patients with ISSS, 59 their healthy 1-st-, 2-nd-, and 3-rd-degree relatives, and 630 controls. Patients with ISSS were divided into subgroups according to gender and clinical variant of the disease. All patients underwent cardiologic examination and molecular genetic testing of DNA.

RESULTS

We revealed significant preponderance of homozygous genotype with rare allele of the studied gene among patients with ISSS compared with control group. In addition, this genotype significantly prevailed among men with SSSU in comparison with the control group.

CONCLUSION

Genotype AA of the SCN10A gene is associated with a predisposition to the development of ISSS.