The Journal of infectious diseases · 2025
Parvovirus B19 and Human Herpes Virus 6B and 7 Are Frequently Found DNA Viruses in the Human Thymus But Show No Definitive Link With Myasthenia Gravis.
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Nowlan Kirsten, Hannolainen Leo, Assimakopoulou Irini M, Dürnsteiner Pia, Sarkkinen Joona, Suokas Santeri, Hedman Lea, Tienari Pentti J, Hedman Klaus, Niku Mikael, Aaltonen Leena-Maija, Huuskonen Antti, Räsänen Jari V, Ilonen Ilkka K, Mäyränpää Mikko I, Dunkel Johannes, Laakso Sini M, Söderlund-Venermo Maria, Perdomo Maria F, Kekäläinen Eliisa
Аннотация
Myasthenia gravis (MG) is a rare autoimmune disorder characterized by muscle weakness resulting from autoantibody-mediated disruption of the neuromuscular junction. Notably, it is also frequently associated with thymic pathology. This study explores the relationship between MG and DNA viruses in the thymus, employing targeted next-generation sequencing and quantitative polymerase chain reaction to analyze thymic tissue samples from both patients with MG and healthy controls. We detected human herpes virus 6B and 7, Epstein-Barr virus, and parvovirus B19 (B19V) across various tissue groups. However, no significant enrichment of these viruses was observed in the thymic tissue of patients with MG.