The European respiratory journal · 2017
Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD.
СтатьяНаблюдательное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Casanova Ciro, Celli Bartolome R, de-Torres Juan P, Martínez-Gonzalez Cristina, Cosio Borja G, Pinto-Plata Victor, de Lucas-Ramos Pilar, Divo Miguel, Fuster Antonia, Peces-Barba Germán, Calle-Rubio Myriam, Solanes Ingrid, Aguero Ramón, Feu-Collado Nuria, Alfageme Inmaculada, De Diego Alfredo, Romero Amparo, Balcells Eva, Llunell Antonia, Galdiz Juan B, Marin Margarita, Moreno Amalia, Cabrera Carlos, Golpe Rafael, Lacarcel Celia, Soriano Joan B, López-Campos José Luis, Soler-Cataluña Juan J, Marin José M
Аннотация
The impact of blood eosinophilia in chronic obstructive pulmonary disease (COPD) remains controversial.To evaluate the prevalence and stability of a high level of blood eosinophils (≥300 cells·μL-1) and its relationship to outcomes, we determined blood eosinophils at baseline and over 2 years in 424 COPD patients (forced expiratory volume in 1 s (FEV1) 60% predicted) and 67 smokers without COPD from the CHAIN cohort, and in 308 COPD patients (FEV1 60% predicted) in the BODE cohort. We related eosinophil levels to exacerbations and survival using Cox hazard analysis.In COPD patients, 15.8% in the CHAIN cohort and 12.3% in the BODE cohort had persistently elevated blood eosinophils at all three visits. A significant proportion (43.8%) of patients had counts that oscillated above and below the cut-off points, while the rest had persistent eosinophil levels <300 cells·μL-1 A similar eosinophil blood pattern was observed in controls. Exacerbation rates did not differ in patients with and without eosinophilia. All-cause mortality was lower in patients with high eosinophils compared with those with values <300 cells·μL-1 (15.8% versus 33.7%; p=0.026).In patients with COPD, blood eosinophils ≥300 cells·μL-1 persisting over 2 years was not a risk factor for COPD exacerbations. High eosinophil count was associated with better survival.