Addiction biology · 2011
Enhanced BDNF serum levels in patients with severe pathological gambling.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Angelucci Francesco, Martinotti Giovanni, Gelfo Francesca, Righino Elisabetta, Conte Gianluigi, Caltagirone Carlo, Bria Pietro, Ricci Valerio
Аннотация
Although the pathophysiology of gambling is unknown, an involvement of midbrain dopaminergic pathway has been hypothesized. In this study, the association between brain-derived neurotrophic factor (BDNF) and pathological gambling was investigated. We measured BDNF serum levels in (1) video players (n=10); (2) card players (n=9); (3) mixed players (n=21; both video and card players) and (4) age-matched controls (n=18). Mixed players had increased BDNF serum levels as compared to controls and higher South Oaks Gambling Screen score as compared to card or video players. Thus, the data demonstrate that patients affected by severe pathological gambling show enhanced BDNF serum levels.