[Research advances in the role of ubiquitin-proteasome pathway in hypertrophic scar].

The ubiquitin-proteasome pathway is a protein degradation pathway that relies on ATP and non-lysosomal pathway in eukaryotic cells. It participates in the regulation of multiple biological processes, including cell cycle, apoptosis, DNA repair, antigen presentation, receptor endocytosis, intracellular signal transduction. Recent studies have found that the ubiquitin-proteasome pathway can participate in the formation and development of hypertrophic scar by regulating transforming growth factor beta/Smad signal transduction and proliferation, differentiation, and apoptosis of fibroblasts. This article summarizes the effects of ubiquitin ligase enzyme, proteasome, and deubiquitinating enzyme in ubiquitin-proteasome pathway in hypertrophic scar, in order to provide new idea for the prevention and treatment of hypertrophic scar.