Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
CONNECT4 APOE: A randomized trial of telephone versus real-time two-way videoconference for disclosure of APOE genotype results in cognitively unimpaired adults.
СтатьяРандомизированное исследованиеМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Wood Elisabeth McCarty, Langbaum Jessica B, Egleston Brian L, Ofidis Demetrios, Cacioppo Cara, Langlois Carolyn M, Weinberg Michelle, Kim Scott Y H, Reiman Eric M, Tariot Pierre N, Roberts J Scott, Karlawish Jason, Bradbury Angela R
Аннотация
INTRODUCTION: Data are needed to inform best practices for disclosing apolipoprotein E (APOE) results given increasing indications for testing.
METHODS: CONNECT4, a multi-center, randomized trial (NCT02978729) compared disclosure of APOE genotype by videoconference or telephone among cognitively unimpaired adults 60-75 years of age. Outcomes were collected at baseline, 2-7 days, 6 weeks, and 6 months.
RESULTS: A total of 301 participants were randomized to telephone and 297 to videoconference disclosure. There were no significant differences between arms for primary or secondary patient-reported outcomes. Moderator analyses found that videoconference reduced depressive symptoms more for older participants (70-75 year), whereas teleconference reduced depressive symptoms more for younger participants (60-64 years) and videoconference increased knowledge for non-White participants as compared to White participants.
DISCUSSION: These data suggest that both telephone and videoconference are reasonable options for disclosure of APOE genotype in cognitively unimpaired individuals. Videoconference disclosure may have some benefits for certain demographic groups.
METHODS: CONNECT4, a multi-center, randomized trial (NCT02978729) compared disclosure of APOE genotype by videoconference or telephone among cognitively unimpaired adults 60-75 years of age. Outcomes were collected at baseline, 2-7 days, 6 weeks, and 6 months.
RESULTS: A total of 301 participants were randomized to telephone and 297 to videoconference disclosure. There were no significant differences between arms for primary or secondary patient-reported outcomes. Moderator analyses found that videoconference reduced depressive symptoms more for older participants (70-75 year), whereas teleconference reduced depressive symptoms more for younger participants (60-64 years) and videoconference increased knowledge for non-White participants as compared to White participants.
DISCUSSION: These data suggest that both telephone and videoconference are reasonable options for disclosure of APOE genotype in cognitively unimpaired individuals. Videoconference disclosure may have some benefits for certain demographic groups.